Die Grundprinzipien der 3% pentobarbital sodium

Die Grundprinzipien der 3% pentobarbital sodium

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There is no antidote for pentobarbital and overdose treatment is symptomatic and supportive. Treatment may require intubation and respiratory support, maintenance of blood pressure with medication and fluids, and maintenance of body temperature.

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However, the use of barbiturates as sedatives rein the postoperative surgical period and as adjuncts to cancer chemotherapy is well established.

IM injection of the sodium salts of barbiturates should be made deeply into a large muscle, and a volume of 5 mL should not Beryllium exceeded at any one site because of possible tissue irritation.

Use in pregnancy: Barbiturates can cause fetal damage when administered to a pregnant woman. Retrospective, case-controlled studies have suggested a connection between the maternal consumption of barbiturates and a higher than expected incidence of fetal abnormalities.

Fluid therapy and other standard treatment for shock, if needed. If renal function is weit verbreitet, forced diuresis may aid hinein the elimination of the barbiturate. Alkalinization of the urine increases renal excretion of some barbiturates, especially phenobarbital, also aprobarbital and mephobarbital (which is metabolized to phenobarbital). Although not recommended as a routine procedure, hemodialysis may be used hinein severe barbiturate intoxications or if the patient is anuric or hinein shock. Patient should be rolled from side to side every 30 minutes. Antibiotics should be given if pneumonia is suspected. Appropriate nursing care to prevent hypostatic pneumonia, decubiti, aspiration, and other complications of patients with altered states of consciousness. DOSAGE AND ADMINISTRATION

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

Barbiturates can cause fetal damage when administered to a pregnant woman. Retrospective, case-controlled studies have suggested a connection between the maternal consumption of barbiturates and a higher than expected incidence of fetal abnormalities. Following oral or parenteral administration, barbiturates readily cross the placental barrier and are distributed throughout fetal tissues with highest concentrations found hinein the placenta, fetal liver, and brain.

These studies have substantial limitations, and it is not clear if the observed effects are due to the anesthetic/sedation drug administration or other factors such as the surgery or underlying illness.

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Barbiturates are metabolized primarily by the hepatic microsomal enzyme Struktur, and the metabolic products are excreted hinein the urine, and less commonly, hinein the feces. Approximately 25 to more info 50 percent of a dose of aprobarbital or phenobarbital is eliminated unchanged in the urine, whereas the amount of other barbiturates excreted unchanged in the urine is negligible.

rein addition, pentobarbital also inhibits the activity of glutamate, the primary stimulatory neurotransmitter rein the brain.

Hinein studies, secobarbital sodium and pentobarbital sodium have been found to lose most of their effectiveness for both inducing and maintaining sleep by the end of 2 weeks of continued drug administration at fixed doses. The short-, intermediate-, and, to a lesser degree, long-acting barbiturates have been widely prescribed for treating insomnia.